Safety of GLP-1 and Dual GLP-1/GIP Receptor Agonists in Preconception, Pregnancy, and Lactation: A Systematic Review of Maternal, Fetal, and Neonatal Outcomes - PubMed
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- #systematic review
- #pregnancy safety
- #GLP-1 receptor agonists
- The systematic review evaluates the safety of GLP-1 and dual GLP-1/GIP receptor agonists during preconception, pregnancy, and lactation, focusing on maternal, fetal, and neonatal outcomes.
- Analysis of 36 studies found no consistent association between periconceptional or early-pregnancy exposure to GLP-1-based therapies and increased risks of major congenital malformations, fetal growth restriction, stillbirth, or neonatal mortality in adjusted comparisons.
- Maternal outcomes, such as gestational diabetes and hypertensive disorders, were heterogeneous without clear safety signals, while data on lactation were limited but indicated minimal drug transfer into human milk.