Cumulative incidence of advanced breast cancer in women aged 40-49 years in the Japan Strategic Anti-cancer Randomised Trial (J-START) of adjunctive ultrasonography: a prespecified secondary analysis
11 hours ago
- #breast cancer
- #screening
- #ultrasonography
- The J-START trial evaluated the long-term effect of adjunctive ultrasonography on advanced breast cancer incidence in women aged 40-49.
- 72,661 asymptomatic women were randomized to receive either ultrasonography with mammography or mammography alone.
- Median follow-up was approximately 11.4 years in the intervention group and 11.3 years in the control group.
- Adjunctive ultrasonography reduced the cumulative incidence of advanced breast cancer (26% vs. 33% in the control group).
- The hazard ratio for advanced cancer was 0.83 (95.6% CI 0.70-0.98; p=0.026).
- Significant divergence in advanced cancer incidence between groups occurred between 48 and 96 months.
- The findings support integrating ultrasonography into screening programs, especially for women with dense breast tissue in Asian populations.
- The study was funded by the Ministry of Health, Labor, and Welfare (Japan) and Japan Agency for Medical Research and Development.