Neurometabolites and Antipsychotic Response in Psychosis: A Mega-Analysis - PubMed
4 hours ago
- #Antipsychotic Response
- #Neurometabolites
- #Psychosis
- Neurometabolite levels differ between antipsychotic nonresponders and responders in psychosis.
- Nonresponders showed elevated medial frontal glutamate, glutamate+glutamine, choline, and myo-inositol compared to responders.
- Similar elevations were observed in nonresponders relative to healthy controls.
- In first-episode psychosis, nonresponders had prospectively elevated medial frontal glutamate+glutamine.
- Myo-inositol elevations were greatest in treatment-resistant individuals.
- Meta-analysis of 23 studies confirmed elevated medial frontal choline and myo-inositol in nonresponse.
- Findings support investigating glutamate-acting and anti-inflammatory interventions for psychosis treatment.