Trial Design and Objectives for Patients With Prostate Cancer: Recommendations From the Prostate Cancer Working Group 4 - PubMed
4 hours ago
- #clinical trials
- #prostate cancer
- #medical imaging
- New imaging approaches and therapies necessitate updated clinical trial guidelines for advanced prostate cancer.
- The Prostate Cancer Working Group 4 (PCWG4) convened to redefine disease terminology and trial practices.
- Focus on androgen pathway modulation and PET imaging for disease assessment.
- Updated recommendations include disease state terminology, eligibility criteria, and response endpoints.
- Emphasis on biomarker-based context for patient benefit and intervention effectiveness.
- Need for validated PET imaging, molecular criteria, and risk stratification in trials.
- Guidance extended to earlier disease states to optimize treatment for diverse populations.