Gestational Diabetes Mellitus and Adverse Maternal and Neonatal Health Outcomes: an Umbrella review of Meta-Analyses - PubMed
5 hours ago
- #neonatal outcomes
- #maternal health
- #gestational diabetes
- Systematic synthesis of evidence on adverse health outcomes related to gestational diabetes mellitus (GDM) via an umbrella review with integrated meta-analyses.
- Included 27 meta-analyses encompassing 85 associations, with 28 significant maternal outcomes and 13 significant neonatal outcomes.
- 11 maternal outcomes (e.g., subclinical atherosclerosis, hypertension, type 2 diabetes) supported by convincing or highly suggestive evidence.
- 3 neonatal outcomes (atrial septal defect, congenital heart disease, ventricular septal defect) were highly suggestive.
- 4 delivery outcomes (hypertensive disorders, cesarean delivery, NICU admission, preterm birth) reached highly suggestive evidence.
- No previously nonsignificant outcomes turned significant upon reanalysis.
- Highlights the need for targeted prevention, management, and further research to clarify causality and refine guidelines.