Effects of Proton Pump Inhibitors on Remodeling and Fibrosis in Eosinophilic Esophagitis - PubMed
6 hours ago
- #Eosinophilic Esophagitis
- #Proton Pump Inhibitors
- #Fibrosis
- PPIs are a first-line treatment for Eosinophilic Esophagitis (EoE) due to their anti-inflammatory effects.
- The study aimed to determine if PPIs affect esophageal remodeling and fibrosis, potentially through TGF-β pathways.
- RNA sequencing of esophageal biopsies from EoE patients pre- and post-PPI treatment identified 746 differentially expressed genes in responders.
- In human esophageal fibroblasts, PPIs attenuated TGF-β-induced fibrotic responses, including collagen deposition and fibroblast motility.
- PPIs reversed approximately 30% of TGF-β-induced gene changes related to fibrosis, with 78 genes consistently affected in both patient biopsies and fibroblasts.
- Functional assays showed PPIs reduce TGF-β-induced reactive oxygen species (ROS) production and collagen deposition.
- The findings suggest PPIs have antifibrotic potential, which may help prevent fibrostenotic progression in EoE.