ZFP161 promotes colorectal cancer progression by transcriptionally activating c-MYC - PubMed
3 days ago
- #ZFP161
- #colorectal cancer
- #c-MYC
- ZFP161 is a key regulator of ATR signaling and maintains genomic stability.
- Human ZFP161 activates c-MYC, while its murine ortholog ZF5 represses c-MYC.
- ZFP161 binds to the c-MYC promoter, modulating its expression and downstream pathways.
- ZFP161 promotes cell proliferation, tumorigenesis, and malignant transformation in RPE-1 cells.
- High ZFP161 expression correlates with poor survival in colon adenocarcinoma patients.
- ZFP161's regulation of c-MYC may be a therapeutic target in c-MYC-driven cancers.