Local Translation in Glial Cells of the Brain - PubMed
5 hours ago
- #local translation
- #neurological disorders
- #glial cells
- Local protein synthesis allows cells with complex architectures to perform compartment-specific functions.
- Translation of mRNAs at distinct subcellular locations enables swift and precise responses to localized stimuli.
- Neurons rely on local translation, and disruptions are linked to neurological disorders like fragile X syndrome, ALS, and spinal muscular atrophy.
- Glial cells (microglia, astrocytes, oligodendrocytes, radial glia) also dynamically use local translation.
- Asymmetric mRNA localization in glial cells suggests key roles in their diverse functions.
- Local translation in glial cells contributes to normal brain function and neurological disease development.