Adrenomedullin Antagonist Nanoparticles Inhibit Breast Cancer Brain Metastasis by Immunomodulating Monocytes/Macrophages - PubMed
6 hours ago
- #immunotherapy
- #breast cancer
- #nanoparticles
- Breast cancer brain metastasis (BCBM) is difficult to treat due to the blood-brain barrier (BBB).
- Monocytes, M2 macrophages, and adrenomedullin (AM) are abundant in human BCBM.
- HPPS nanoparticles effectively target monocytes/macrophages.
- AMA-HPPS nanoparticles can immunomodulate monocytes/macrophages into antitumor effector cells.
- AMA-HPPS-CpG enhances monocyte targeting and immunomodulation, inhibiting BCBM and prolonging survival in mice.
- The nanoparticles activate the NF-κB pathway, reprogramming the immunosuppressive tumor microenvironment.
- This study presents a novel immunotherapy strategy for brain metastasis by targeting monocytes/macrophages.