Wheat fiber mitigates colitis via non-SCFA microbial metabolite-trained intestinal macrophages - PubMed
5 hours ago
- #wheat fiber
- #colitis
- #microbiota
- Wheat fiber (WF) enrichment in diets protects mice against colitis, independent of short-chain fatty acids (SCFAs).
- Protection is linked to microbiota diversity preservation, especially Bacteroides thetaiotaomicron (B. theta), essential for WF's colitis protection.
- B. theta presence leads to WF-induced metabolites that reprogram macrophages to an M2-like phenotype, reducing intestinal inflammation.
- Reprogrammed macrophages, when transplanted into mice, replicate WF's protective effects against colitis.
- Findings suggest a mechanism by which WF consumption may prevent inflammatory bowel disease (IBD).