Intratumoral bacterium Enterocloster bolteae promotes hepatocellular carcinoma progression by directly binding tumor cells - PubMed
4 hours ago
- #Enterocloster bolteae
- #MAPK signaling
- #Hepatocellular carcinoma
- Enterocloster bolteae is enriched in the feces of HCC patients and linked to poor prognosis.
- E. bolteae disrupts intestinal barrier integrity, translocates to the liver, and promotes tumor proliferation.
- The bacterium's surface protein PbpT interacts with tumor cell receptor DSG1, attenuating its tumor-suppressive function.
- PbpT-DSG1 interaction activates the MAPK signaling pathway, accelerating HCC progression.
- Blocking PbpT prevents E. bolteae attachment and its tumor-promoting effects, suggesting a potential therapeutic target.