A single-cell atlas of the human airways from patients with allergic rhinitis comorbid with asthma - PubMed
6 hours ago
- #single-cell RNA sequencing
- #allergic rhinitis with asthma
- #airway epithelium
- A single-cell RNA sequencing study analyzed nasal and bronchial brush cells from patients with allergic rhinitis comorbid with asthma (ARcoAS) and healthy volunteers.
- Similar cell profile alterations were observed in both upper and lower airways under chronic inflammation, with many shared up-regulated and down-regulated genes between the two regions.
- Impaired ciliated cell structure and epithelial barrier function were found in diseased airways, along with reduced intercellular communication between epithelial and immune cells in ARcoAS.
- The study identified the GZMA-PARD3 pathway as a disruptor of the airway epithelial barrier in vitro, suggesting a mechanism for disease pathology.
- Compromised ciliated cells and aberrant basal cell proliferation may drive eosinophilic inflammation in response to type 2 inflammation in ARcoAS, offering potential targets for tailored treatments.