PGK1 Drives Cardiac Hypertrophy by Regulating the Vimentin/PI3K/Akt Pathway - PubMed
6 hours ago
- #cardiac hypertrophy
- #PGK1
- #ferroptosis
- PGK1 (phosphoglycerate kinase 1) is implicated in pathological cardiac hypertrophy, a major risk factor for heart failure.
- PGK1 activation and upregulation were observed in myocardium tissues from both mice and patients with cardiac hypertrophy.
- Cardiomyocyte-specific PGK1-deficiency alleviated cardiac hypertrophy and dysfunction, while overexpression or 3-phosphoglycerate infusion worsened it.
- PGK1 acts as a protein kinase, stimulating vimentin phosphorylation (Ser83), leading to FAK/Src-mediated PI3K/Akt phosphorylation and promoting cardiomyocyte ferroptosis.
- Inhibition of PGK1 by CBR-470-1 prevented cardiac hypertrophy in cellular and animal models.
- The study highlights PGK1's role in myocardial hypertrophy via the vimentin/PI3K/Akt/ferroptosis pathway.