Methionine metabolism is linked with phospholipid and glutamine metabolism to drive ferroptosis - PubMed
6 hours ago
- #cancer metabolism
- #ferroptosis
- #methionine metabolism
- Methionine is essential for ferroptosis induced by cysteine deprivation.
- In lung cancer cells, methionine is directed into polyamine synthesis via the salvage pathway rather than the transsulfuration pathway.
- Depletion of methionine reduces glutamine catabolism and promotes ACSL4 degradation, affecting phospholipid metabolism.
- Supplementation with S-adenosylmethionine (SAM) can restore metabolic balance and sensitivity to ferroptosis.