Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson's disease - PubMed
8 hours ago
- #Parkinson's Disease
- #Beta Oscillations
- #Transcranial Ultrasound
- Transcranial ultrasound stimulation (TUS) is an emerging non-invasive method for modulating deep brain structures.
- A randomized controlled cross-over study tested pallidal TUS pulsed at 130 Hz on subthalamic beta-band activity in four male Parkinson's Disease (PD) participants.
- Beta-band power in the ipsilateral subthalamic nucleus (STN) reduced by 10.34%, showing statistically significant suppression of pathological oscillations.
- Reduction in beta power correlated between the ipsilateral STN and primary motor cortex, but not the contralateral STN.
- Bradykinesia, measured by reaction time, reduced by 17.70%, indicating improvement in motor symptoms.
- This proof-of-concept study suggests TUS can suppress pathological oscillations, potentially enabling therapeutic applications for PD.