MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and are Clinically Relevant Across Central Nervous System Disorders - PubMed
5 hours ago
- #MIF
- #CD74
- #brain metastasis
- CD74+ microglia/macrophages, induced by interferon gamma in brain metastases, do not follow the canonical MHC-II antigen presentation pathway.
- Cancer cells produce MIF, which binds to CD74, triggering NF-κB activation and promoting metastatic progression.
- A CD74 signature correlates with aggressive brain metastasis but not with primary tumors.
- A pan-disease CD74+ myeloid signature is found in Alzheimer's disease and multiple sclerosis.
- Ibudilast, a brain-penetrant drug blocking MIF-CD74 binding, reduces brain metastasis in models and patient-derived cultures.
- MIF/CD74 reprogramming of myeloid cells presents a therapeutic target for brain metastases and other CNS disorders.