Efficacy and Safety of Tetracyclines in Bone and Joint Infections: A Literature Review - PubMed
5 hours ago
- #Bone and Joint Infections
- #Multidrug-Resistant Pathogens
- #Tetracyclines
- Tetracyclines offer favorable bone penetration and oral bioavailability with activity against multidrug-resistant pathogens.
- Experimental studies show strong bone affinity but inconsistent tissue concentrations and insufficient monotherapy against biofilms.
- Clinical trials found tetracyclines inferior to standard regimens, though observational studies show variable efficacy (40-80%) in salvage therapy for MDR infections.
- Tolerability issues include frequent gastrointestinal intolerance.
- Guidelines recommend tetracyclines for zoonotic infections (e.g., Brucella) and as suppressive therapy in select prosthetic joint infections, but evidence is weak compared to fluoroquinolones.
- Data are heterogeneous, largely observational; robust prospective studies are needed, especially for newer agents like omadacycline and eravacycline.