Association between non-traditional lipid-inflammatory parameters and incident diabetes: a national prospective cohort study - PubMed
5 hours ago
- #lipid-inflammatory parameters
- #diabetes
- #prospective cohort study
- Non-traditional lipid-inflammatory parameters are linked to a higher risk of incident diabetes.
- The study included 7,356 participants, with 1,173 developing diabetes over a median follow-up of 9 years.
- Higher baseline and cumulative levels of lipid-inflammatory parameters, especially LCI-hsCRP, were associated with elevated diabetes risk (HR = 2.03, 95% CI: 1.70-2.41).
- All lipid-inflammatory parameters showed nonlinear associations with diabetes risk.
- LCI-hsCRP exhibited the highest predictive value (AUC = 0.619, 95% CI: 0.597-0.640).
- Mediation analyses revealed bidirectional mediation between non-traditional lipid indices and hsCRP for diabetes risk.
- The study was conducted using data from the China Health and Retirement Longitudinal Study (2011-2020).