Identification of GLDN+ odontogenic stem cells as crucial for human tooth development and regeneration - PubMed
5 hours ago
- #dental papilla
- #odontogenic stem cells
- #tooth regeneration
- The dental papilla (DP) is essential for dentin and pulp development.
- Single-cell sequencing identified Gliomedin (GLDN)+ DP stem cells (DPSCs) as key progenitors in early tooth development.
- GLDN+ DPSCs show enhanced self-renewal, migration, and odontogenic differentiation compared to GLDN- DPSCs.
- These cells play a crucial role in inducing endothelial cell migration and tube formation, vital for tooth development.
- GLDN+ DPSCs can regenerate vascularized dental pulp with an odontoblast layer in vivo.
- GLDN maintains the phenotype and function of GLDN+ odontogenic stem cells (OSCs) via BMP5 signaling.
- This study identifies GLDN+ OSCs as a critical subpopulation for dental pulp development and regeneration.