The correlation between cardiac T2*MRI and B-Type natriuretic peptides in patients with transfusion-dependent anemias and systemic iron overload: a systematic review and meta-analysis - PubMed
5 hours ago
- #natriuretic peptides
- #T2*MRI
- #cardiac iron overload
- Systematic review and meta-analysis evaluates the correlation between cardiac T2*MRI and B-type natriuretic peptides (BNP/NT-proBNP) in transfusion-dependent anemia patients with systemic iron overload.
- Cardiac T2*MRI is the gold standard for myocardial iron assessment but is costly and less accessible; natriuretic peptides may serve as a practical biomarker alternative.
- Pooled data from seven studies (783 patients) showed a moderate inverse correlation (r = -0.30) between T2* values and natriuretic peptide levels, indicating higher peptides with greater iron deposition.
- Patients with cardiac iron overload (T2* < 20 ms) had significantly higher natriuretic peptide levels (321.1 vs. 179.0 pg/mL) compared to those without (T2* > 20 ms).
- Natriuretic peptides reflect myocardial stress from iron burden and may aid in screening/monitoring where MRI is unavailable, though they cannot replace MRI entirely.
- Further prospective studies are needed to validate their role in longitudinal risk prediction.