ATOJIN: A Natural Products Mixture, Alleviates Atopic Dermatitis in DNCB-Induced NC/Nga Mice - PubMed
4 hours ago
- #Natural Products
- #Anti-inflammatory
- #Atopic Dermatitis
- ATOJIN is a natural product mixture with anti-inflammatory properties, composed of Phellodendron amurense, Schizonepeta tenuifolia, Sophora flavescens, Glycyrrhiza uralensis, and Liriope platyphylla.
- The study evaluates ATOJIN's therapeutic potential in a DNCB-induced atopic dermatitis (AD) mouse model, focusing on inflammation and immune regulation.
- ATOJIN significantly improved AD symptoms in mice, including dermatitis scores, ear thickness, and spleen weight reduction.
- It reduced epidermal thickness and the infiltration of inflammatory and mast cells in the skin.
- ATOJIN modulated serum IgE levels and pro-inflammatory cytokines (IL-2, IL-4, IL-6, TNF-α), indicating systemic anti-inflammatory effects.
- The efficacy of ATOJIN was comparable or superior to the standard topical treatment tacrolimus, suggesting its potential as an oral therapeutic for AD.