A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder - PubMed
5 hours ago
- #randomized clinical trial
- #transcranial alternating current stimulation
- #major depressive disorder
- A multicenter randomized clinical trial evaluated the efficacy and safety of 10 Hz HD-tACS targeting the bilateral DLPFC in 120 adults with MDD over 4 weeks of treatment and 4 weeks of follow-up.
- Active HD-tACS led to a significantly greater reduction in depression scores compared to sham (48% vs 24%), with sustained effects and additional improvements in anxiety, sleep, and quality of life.
- Adverse events were minimal, including two cases of hypomania, but no serious adverse events, indicating good tolerability.
- The trial supports HD-tACS as an effective intervention for MDD, suggesting further research on neural mechanisms and optimized protocols.