Andrographis exerts antitumor effects and enhances 5‑FU efficacy via the alteration of ferroptosis‑related genes in esophageal squamous cell carcinoma - PubMed
6 hours ago
- #Andrographis
- #ESCC
- #Ferroptosis
- Andrographis shows antitumor effects in esophageal squamous cell carcinoma (ESCC).
- It enhances the efficacy of 5-fluorouracil (5-FU) by altering ferroptosis-related genes.
- In vitro experiments demonstrated inhibition of cell proliferation and colony formation.
- Andrographis induces apoptosis and upregulates ferroptosis-related genes like HMOX1, GCLC, and GCLM.
- Combination with 5-FU at sub-IC50 doses results in additive antitumor effects.
- Potential as adjunctive therapy to improve efficacy and reduce 5-FU dosage and toxicity.