Dendritic Cells Remodel Eccrine Sweat Gland Niche Metabolism Via Oxidative Phosphorylation During Aging - PubMed
5 hours ago
- #dendritic cells
- #sweat glands
- #aging
- Dendritic cells (DCs) around sweat gland coils are reduced in aged skin.
- DCs in youthful skin support sweat gland oxidative phosphorylation via NAMPT-INsulin receptor signaling.
- Aging leads to macrophage migration inhibitory factor secretion from sweat glands, impairing DC function through CD74 and CYBB.
- This creates a deteriorating feedback loop that exacerbates gland decline.
- The study identifies a reversible, niche-dependent mechanism of age-related sweat gland decline.