Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Both Kidney Recipients From the Same Donor: Was It Graft Transmission? - PubMed
5 hours ago
- #Prion Disease
- #Iatrogenic Transmission
- #Kidney Transplantation
- Both kidney recipients from the same donor developed rapidly progressive dementia, with one confirmed as sporadic Creutzfeldt-Jakob disease (CJD).
- Current iatrogenic CJD diagnostic criteria do not include solid organ transplantation as a recognized transmission pathway, but this case suggests it could be a route for prion transmission.
- This case highlights the diagnostic challenges in transplant recipients when neurological symptoms arise, advocating for increased awareness and use of appropriate diagnostic tools for prion diseases.