A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone-Mediated C2C12 Muscle Atrophy - PubMed
5 hours ago
- #C2C12 myotubes
- #muscle atrophy
- #dexamethasone
- Systematic review on dexamethasone-mediated C2C12 muscle atrophy.
- Dexamethasone treatment consistently reduces myotube diameter and fusion index.
- Increased expression of atrophic markers like Atrogin-1 and MuRF1 observed.
- Reduction in anabolic signaling (mTORC, Akt) and mitochondrial function noted.
- Findings support dexamethasone as a reliable model for muscle pathology studies.