Astrocytic H3 receptors regulate anxiety through GABA signaling - PubMed
3 days ago
- #astrocytes
- #anxiety
- #GABA
- Anxiety disorders are prevalent but current treatments are limited.
- Histamine is implicated in neuropsychiatric disorders and may regulate anxiety.
- Anxiogenic exposure triggers histamine release in ventral hippocampal CA1 (vCA1).
- Histaminergic circuit in vCA1 regulates anxiety via astrocytic H3 receptors (H3Rs).
- Ablation of astrocytic H3Rs reduces anxiety-related astrocytic responses and increases anxiety via GABA signaling.
- Chronic stress upregulates vCA1 astrocytic H3R expression; enhancing H3R signaling can reduce maladaptive anxiety.
- Astrocytic H3Rs are potential therapeutic targets for anxiety disorders.