A Biologically Lubricating Allicin-Based Nanoplatform for Remodeling the Inflammation-Senescence Axis in the Treatment of Periodontitis - PubMed
5 days ago
- #nanoplatform
- #inflammation-senescence axis
- #periodontitis
- A biologically lubricating allicin-based nanoplatform (PPCG) is developed to treat periodontitis by remodeling the inflammation-senescence axis.
- PPCG integrates a hydration-lubricating diblock copolymer (PDMPC) with bioactive allicin to create a dual protective barrier.
- The lubricating PDMPC barrier suppresses pathogenic microbial adhesion and biofilm formation, acting as an 'outer fortress wall'.
- Allicin release regulates bone marrow mesenchymal stem cells (BMMSCs), mitigates inflammation, and promotes tissue regeneration, forming an 'inner defensive citadel'.
- PPCG attenuates periodontal tissue senescence, inflammation, and prevents alveolar bone loss in a mice periodontitis model.
- The nanoplatform rebalances oral microbiota and maintains ecological homeostasis.
- Therapeutic efficacy is validated using an AI-assisted detection system based on the YOLO v8 deep learning model.
- This approach offers a scalable and translational strategy for treating periodontitis.