RAS/ERK signaling and PLK1: Coordinating developmental regulation and disease mechanisms - PubMed
7 days ago
- #RAS/ERK signaling
- #PLK1
- #developmental biology
- RAS/ERK signaling pathway regulates cellular processes like proliferation, differentiation, and survival.
- Dysregulation of RAS/ERK signaling is linked to developmental disorders (RASopathies) and cancers.
- PLK1 is essential for meiotic and mitotic cell cycles and plays a key role in development.
- Abnormal ERK signaling can mimic PLK1 deficiency phenotypes, indicating pathway intersection.
- The review explores connections between RAS/ERK and PLK1 signaling in development.