Exercise-derived exosomes mediate crosstalk between skeletal muscle, adipose tissue, and bone: mechanisms of inter-organ communication and tissue adaptation - PubMed
6 hours ago
- #inter-organ communication
- #exosomes
- #exercise physiology
- Inter-organ communication among bone, skeletal muscle, and adipose tissue is crucial for metabolic homeostasis and musculoskeletal health.
- Exercise-derived exosomes act as key mediators by transporting microRNAs and bioactive molecules that modulate signaling pathways across these tissues.
- Exercise regulates exosome biogenesis and cargo, enhancing tissue synergy and alleviating age-related metabolic dysfunction and degeneration.
- Exercise-induced exosomal miRNAs show therapeutic potential by targeting inflammation, mitochondrial function, and anabolic-catabolic balance.