RAS pathway activation and microenvironmental adaptation as hallmarks of myeloid sarcoma - PubMed
3 hours ago
- #Myeloid sarcoma
- #RAS pathway
- #Extramedullary AML
- Myeloid sarcoma is an aggressive extramedullary subtype of AML occurring in about 20% of patients.
- It evolves from medullary AML but has distinct site-specific clonal evolution and unique transcriptional signatures.
- Key hallmarks include RAS pathway activation and microenvironmental adaptation.
- Circulating tumor DNA sequencing offers a non-invasive approach for molecular profiling of myeloid sarcoma.
- Differences between medullary AML and myeloid sarcoma include universal molecular evolution.