Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor - PubMed
3 hours ago
- #Ulcerative Colitis
- #Butyrate
- #Pyroptosis
- Butyrate from gut microbiota inhibits colonic epithelial pyroptosis to alleviate colitis.
- Activation of aryl hydrocarbon receptor (AhR) by butyrate suppresses the cGAS-STING-NF-κB pathway.
- Fecal microbiota transplantation (FMT) increased butyrate-producing bacteria and butyrate levels.
- GSDMD knockout reduced colitis, and butyrate had no additional effect in GSDMD-knockout mice.
- AhR silencing reversed butyrate's protective effects in cellular models of pyroptosis.