Endothelial IRE1 signaling maintains blood-brain barrier integrity and limits neuroinflammation after traumatic brain injury - PubMed
3 months ago
- #Traumatic Brain Injury
- #Blood-Brain Barrier
- #Neuroinflammation
- Endothelial IRE1 signaling is crucial for maintaining blood-brain barrier (BBB) integrity after traumatic brain injury (TBI).
- Loss of IRE1 in endothelial cells (ECs) worsens BBB disruption, increases immune cell infiltration, and amplifies neuroinflammation.
- RNA-sequencing identified Cxcl10 as a key chemokine linked to increased leukocyte recruitment in endothelial IRE1 deficiency.
- Treatment with tauroursodeoxycholic acid (TUDCA) suppressed Cxcl10 expression and improved motor function post-TBI.
- Modulating ER stress in brain ECs may offer a therapeutic strategy to reduce secondary injury after TBI.