DDX6 induces immunosuppression in cancer by disrupting structural stability of endogenous double-stranded RNAs - PubMed
3 hours ago
- #DDX6
- #RNA editing
- #cancer immunotherapy
- DDX6 acts as an immunosuppressor in cancer by interacting with ADAR1 to repress A-to-I RNA editing, disrupting dsRNA stability.
- This suppression of editing prevents immune activation by endogenous dsRNA, inhibiting interferon signaling and immune responses.
- Depletion of DDX6 in tumor cells leads to dsRNA accumulation, activating intrinsic and extrinsic immunity to hinder tumor growth.
- The study challenges the view that RNA editing always destabilizes dsRNA, showing it can stabilize dsRNA via I-C pairing, which DDX6 suppresses.
- Targeting DDX6 could be a promising strategy for cancer immunotherapy by promoting tumor cell-intrinsic innate immune activation.