Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancy - PubMed
3 days ago
- #gut microbiota
- #neurodevelopment
- #antenatal depression
- Antenatal depressive symptoms (AND) at any trimester are associated with delayed infant neurodevelopment.
- Maternal gut microbiota dysbiosis in AND involves reduced butyrate-producing bacteria and disrupted amino acid metabolism.
- Fecal microbiota transplantation from AND mothers to germ-free dams impaired fetal brain development and postnatal cognitive function.
- Maternal butyrate supplementation partially rescues molecular and neurodevelopmental abnormalities.
- Findings suggest gut microbiota and metabolites are therapeutic targets for preventing intergenerational effects of antenatal depression.