APOE ε4 influences the widespread TDP-43 pathological subtype in sporadic amyotrophic lateral sclerosis - PubMed
3 days ago
- #TDP-43 pathology
- #ALS
- #APOE ε4
- APOE ε4 is linked to a more widespread TDP-43 pathology subtype in sporadic ALS, distinct from motor region-restricted patterns.
- Study of 145 autopsy-confirmed cases showed APOE ε4 carriers had higher rates of type 2 pathology (widespread cortical involvement).
- Bayesian structural equation modeling indicated APOE ε4 directly influences TDP-43 subtype, independent of amyloid-β and tau pathology.
- Rare variants in ALS-associated genes did not significantly affect TDP-43 pathological distribution.
- Incorporating APOE genotype into ALS stratification could aid in developing subtype-specific therapeutic approaches.