Decoding the origins of cellular self-organization for engineered biology - PubMed
4 hours ago
- #stem cell biology
- #cellular self-organization
- #tissue engineering
- Cellular self-organization evolved for multicellular coordination, driven by fundamental constraints like oxygen and nutrient transport.
- Physical laws lead to collective behaviors including cavitation, folding, and branching, integrating mechanics, signaling, and gene regulation for precise tissue and organ development.
- Stem cell models of embryogenesis and organogenesis provide tractable systems to uncover developmental rules, trajectories, and failure modes, highlighting bottlenecks and constraints.
- Understanding morphogenesis' principles can enable regenerative strategies, allowing for the simulation and rational engineering of living tissue architectures.