Long‑term outcomes of prophylactic cranial irradiation in high‑risk metastatic NSCLC: Final PRoT‑BM analysis - PubMed
5 hours ago
- #Brain metastases
- #Non-small-cell lung cancer
- #Prophylactic cranial irradiation
- Prophylactic cranial irradiation (PCI) reduces brain metastases (BM) risk by 60% in high-risk metastatic NSCLC.
- PCI significantly improves overall survival (OS) with median OS of 30.51 months vs. 19.23 months in the control group.
- Long-term neurocognitive function (NCF) remains stable in PCI-treated patients, with no evidence of progressive radiation-related neurotoxicity.
- Leptomeningeal carcinomatosis events were infrequent, with no significant difference between PCI and control groups.
- The study suggests durable benefits of PCI in reducing BM incidence and prolonging OS, warranting further phase III trials.