Dentate gyrus microglial dynamics contributes to high-fat diet-induced depression-like behaviors in mice - PubMed
5 hours ago
- #depression
- #high-fat diet
- #microglia
- High-fat diet (HFD) consumption increases the risk of depression, but the mechanisms are unclear.
- A decline in microglia in the dentate gyrus, following initial activation, is linked to depression pathogenesis.
- 12-week HFD in mice induced depression-like behaviors and reduced, dystrophic microglia in the dentate gyrus.
- Initial microglial activation and subsequent damage mediated the reduction in dentate gyrus microglia under HFD.
- Minocycline suppressed initial microglial activation, preventing HFD-induced microglial damage and depression-like behaviors.
- Lipopolysaccharide (LPS) restored microglia numbers in HFD mice and reversed depression-like behaviors.
- Modulating microglial dynamics may help prevent or treat depression linked to high fat intake.