Histone H3K9 lactylation activates the TXNIP/NLRP3 pathway to drive macrophage inflammation after spinal cord injury - PubMed
7 hours ago
- #H3K9la
- #Macrophage inflammation
- #Spinal cord injury
- Histone H3K9 lactylation (H3K9la) activates the TXNIP/NLRP3 pathway, driving macrophage inflammation after spinal cord injury (SCI).
- Lactate accumulation in SCI patients and mice leads to increased H3K9la in macrophages and monocytes.
- TXNIP is identified as a direct target of H3K9la, exacerbating inflammation and impairing mitochondrial function.
- Glycolytic inhibition reverses lactate-induced inflammation and mitochondrial dysfunction in vitro.
- A hypoxia-responsive peptide inhibitor (H3K9la-pe) reduces macrophage lactylation, inflammation, and promotes axon regeneration in SCI mice.
- Blocking macrophage H3K9la is a promising therapeutic strategy for SCI.