A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice - PubMed
5 hours ago
- #mouse model
- #Yezo virus
- #antiviral testing
- Development of a mouse-adapted Yezo virus (MA-YEZV) strain causing lethal infection in immunocompetent mice.
- MA-YEZV mirrors human infection symptoms: thrombocytopenia, leukopenia, and severe liver injury.
- Serial passaging in mice led to 31 non-synonymous mutations, enhancing viral replication and pathogenicity.
- MA-YEZV shows broad tissue tropism, highest viral loads in the liver, and induces a strong inflammatory response.
- Ribavirin treatment effectively suppresses viral replication and prevents mortality, while remdesivir shows no efficacy.
- The model serves as a tool for studying YEZV pathogenesis and antiviral development.
- Identified mutations provide insights into viral adaptation and virulence mechanisms.