Dual-Pronged Strategy on Autoimmune Uveitis by Topical Application of Bioactive Carbon Dots from Natural Herbs - PubMed
5 hours ago
- #autoimmune uveitis
- #topical treatment
- #carbon dots
- The study introduces a noninvasive topical treatment for autoimmune uveitis using HSCDs, bioactive carbon dots derived from natural herbs, administered as eye drops.
- HSCDs exhibit strong scavenging capacity against reactive oxygen and nitrogen species (RONS) and can penetrate from the ocular surface into the retina.
- In an experimental autoimmune uveitis mouse model, the treatment showed dual therapeutic effects: alleviating oxidative stress, inhibiting microglial M1 activation via the Nrf2/HO-1 pathway, and reducing inflammation in retinal vascular endothelial cells, while restoring vascular homeostasis.
- A biosafety assessment confirmed that HSCDs have favorable biocompatibility and immunological safety, establishing them as a safe and effective nanotherapeutic for autoimmune uveitis.