Dihydroartemisinin Alleviates Neuronal Damage and Seizures in Epileptic Mice by Inhibiting Ferroptosis via the SIRT1/FOXO1/SLC7A11/GPX4 Pathway - PubMed
11 hours ago
- #neuroprotection
- #epilepsy
- #ferroptosis
- Dihydroartemisinin (DHA) alleviates neuronal damage and seizures in epileptic mice by inhibiting ferroptosis.
- DHA activates the SIRT1/FOXO1/SLC7A11/GPX4 pathway to suppress ferroptosis, providing neuroprotective effects.
- Experimental results show DHA reduces seizures, hippocampal damage, and cognitive deficits in mice.
- DHA increases SLC7A11 and GPX4 expression, key markers in ferroptosis inhibition.
- Clinical evidence supports the link between ferroptosis and temporal lobe epilepsy (TLE).
- The study suggests DHA as a potential therapeutic agent for epilepsy through ferroptosis regulation.