Formate reduces ischemic injury in the male heart by increasing protein S -nitrosation - PubMed
4 hours ago
- #cardioprotection
- #ischemic heart disease
- #protein S-nitrosation
- Formate reduces ischemic injury in male hearts by increasing protein S-nitrosation (SNO).
- Nitric oxide (NO) signaling and protein S-nitrosation play a key role in reducing ischemic injury.
- Female endogenous protection is linked to formate, but here, formate's efficacy is investigated in male hearts.
- Formate protection in ex vivo and in vitro models involves preserving post-ischemic tetrahydrobiopterin (BH4) levels.
- Formate enhances protein SNO levels through a nitric oxide synthase (NOS)-dependent mechanism.
- Inhibition of dihydrofolate reductase (DHFR) blunts formate-mediated protection, highlighting one-carbon enzyme involvement.
- These findings suggest formate is a potent cardioprotective agent with implications for treating ischemic heart disease in males.