RBFOX1 association with age at onset of Alzheimer's disease - PubMed
5 hours ago
- #Alzheimer's disease
- #RBFOX1
- #genetic linkage
- RBFOX1 gene is associated with the age at onset of Alzheimer's disease (AD).
- The study identified RBFOX1 through genome-wide linkage analysis in early-onset AD families.
- RBFOX1 variants were linked to age at onset and cognitive phenotypes across multiple validation cohorts.
- Blood transcriptomics showed RBFOX1 overexpression correlates with earlier onset of AD.
- RBFOX1 is proposed as a potential therapeutic target for delaying or preventing dementia.