Mediating role of the systemic immune-inflammation index in obesity-induced glycolipid dysmetabolism and compromised IVF/ICSI outcomes in polycystic ovary syndrome: A retrospective cohort study - PubM
5 hours ago
- #PCOS
- #IVF/ICSI outcomes
- #systemic immune-inflammation index
- The study investigates the mediating role of the systemic immune-inflammation index (SII) in obesity-induced glycolipid dysmetabolism and IVF/ICSI outcomes in PCOS.
- 598 women with PCOS undergoing their first IVF/ICSI cycle were included in the study.
- Higher levels of TG/HDL, TC/HDL, LDL/HDL, and HOMA-IR showed negative correlations with oocyte yield, fertilization rate, embryo quality, and live birth rate.
- Elevated SII was an independent predictor of reduced live birth rate and mediated 8.8% to 10.7% of the adverse effects of dyslipidemia on live birth.
- The study suggests that targeting both metabolism and inflammation may optimize fertility success in PCOS patients.