Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in temporomandibular joint osteoarthritis induced by different types of occlusal disorder - PubMed
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- #single-cell transcriptomics
- #immune-chondrocyte crosstalk
- #TMJ osteoarthritis
- Single-cell transcriptional atlas reveals distinct immune-chondrocyte crosstalk mechanisms in TMJ osteoarthritis induced by different occlusal disorders.
- Identified chondrocyte heterogeneity and subchondral immune microenvironments in mouse mandibular condyle using single-cell transcriptomes.
- Differentially expressed gene patterns distinguished 8 chondrocyte subsets and 9 immune cell types in the condyle.
- Enhanced communication between chondrocytes and immune cells in condyles subjected to APC or UAC models.
- Neutrophils play a predominant role in immune-chondrocyte interactions in occlusal disorder models.
- Neutrophils-derived TNF-α signaling was most enhanced in the APC model, while Thbs1-Sdc4 signaling was prominent in the UAC model.
- Drug interference in these signaling pathways demonstrated therapeutic potential for TMJOA.