Agarotriose Alleviates Colitis by Promoting Akkermansia muciniphila-Derived Spermidine Production to Suppress PI3K/AKT/NF-κB Signaling - PubMed
12 hours ago
- #Agarotriose
- #Akkermansia muciniphila
- #Colitis
- Agarotriose (A3), a marine-derived oligosaccharide, shows anti-inflammatory effects in colitis.
- A3's protective effects depend on gut microbiota, particularly enriching Akkermansia muciniphila.
- A3 promotes A. muciniphila growth and increases spermidine production, which improves colitis symptoms.
- Spermidine attenuates inflammation by modulating the PI3K/AKT/NF-κB signaling pathway.
- A3 may serve as a promising marine-derived prebiotic for intestinal health.