Curcumin augments mitophagy via Nrf2-PINK1-mediated, Parkin-dependent ubiquitination to suppress ferroptosis in post-cardiac arrest brain injury - PubMed
5 days ago
- #Mitophagy
- #Ferroptosis
- #Curcumin
- Curcumin (Cur) shows neuroprotective effects in post-cardiac arrest brain injury (PCABI).
- The study evaluates Cur's efficacy in PCABI, focusing on mitophagy and ferroptosis regulation.
- Cur improves neurological outcomes and reduces brain damage in CA/CPR rat models.
- Mechanistically, Cur reduces iron overload, lipid peroxidation, and enhances mitophagy via Nrf2-PINK1-Parkin pathway.
- Cur binds to Keap1, promoting Nrf2 nuclear translocation and activation of downstream genes.
- The findings highlight Cur's potential as a therapeutic agent after cardiac arrest.