MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation - PubMed
8 hours ago
- #PAPS phosphatase
- #sulfation regulation
- #MESH1
- MESH1 is identified as a metazoan PAPS phosphatase, hydrolyzing PAPS to adenosine-5'-phosphosulfate and phosphate.
- MESH1 localizes to the Golgi and regulates sulfated glycosaminoglycan (sGAG) production; its knockdown increases sGAG in chondrogenic cells.
- Mesh1 knockout in brachymorphic mice raises sGAG in joint cartilage and improves bone density.
- Overexpression of MESH1 in Caenorhabditis elegans reduces PAPS levels, alleviating neurotoxic PAP accumulation.
- The study establishes MESH1 as a key regulator of sulfation with therapeutic potential for sulfation-related disorders.